Risk Factors for Developing Venous Insufficiency

posted in: Varicose Veins

Venous insufficiency, also known as chronic venous insufficiency (CVI), is a medical condition where the veins, predominantly in the lower extremities, fail to return blood to the heart efficiently. This insufficiency is often due to defective vein valves or walls, leading to blood pooling in the legs, a state referred to as venous stasis.

This condition can result in various symptoms such as swelling, leg pain, skin changes, and in more severe cases, leg ulcers. Beyond mere discomfort, venous insufficiency can significantly impact an individual’s quality of life, necessitating a thorough understanding of its risk factors and prevention methods.

Turning our focus to the UK, venous insufficiency is far from a rare condition. According to the landmark Edinburgh Vein Study conducted in the early 2000s, the age-adjusted prevalence of chronic venous insufficiency in the UK was approximately 9% in men and 7% in women. This statistic translates to roughly 1 in 11 people in the UK grappling with this condition. Furthermore, the prevalence of trunk varies; a common manifestation of venous insufficiency, often presenting as varicose veins, was 40% in men and 32% in women.

*While these figures are based on data that is now over two decades old, they do provide a solid starting point in understanding the widespread nature of venous insufficiency.

Risk Factors for Developing Venous Insufficiency - Vein Solutions

Understanding Venous Insufficiency

The venous system is integral to our circulatory system, returning deoxygenated blood from the body’s tissues to the heart. Veins are elastic, tubular structures equipped with one-way valves that prevent the backflow of blood, ensuring its unidirectional movement towards the heart.

In the lower extremities, we have two primary types of veins: the superficial veins, which lie just beneath the skin, and the deep veins, which are located within the muscles. Superficial veins drain into the deep veins, carrying the blood toward the heart. When standing or sitting, the upward movement of blood is facilitated by muscle contractions, in what’s known as the ‘calf muscle pump’. The one-way valves in the veins prevent the blood from falling back down due to gravity.

Pathophysiology of Venous Insufficiency

Venous insufficiency occurs when the venous return from the lower extremities to the heart is impaired. This can result from any condition that weakens or damages the venous valves or the venous walls, resulting in venous stasis or blood pooling in the lower legs.

When the venous valves are defective, they fail to prevent the backflow of blood, especially when standing. Similarly, if the vein walls lose their elasticity or weaken (as seen in conditions like varicose veins), they can dilate and cause the valves to become incompetent. In both scenarios, the malfunctioning valves allow blood reflux, contributing to venous stasis.

Furthermore, damage to the deep veins from conditions such as deep vein thrombosis (DVT) can obstruct blood flow and result in venous insufficiency.

The prolonged venous stasis leads to an increase in venous pressure, a state known as venous hypertension. This increased pressure can cause fluid to leak out into the surrounding tissues, leading to swelling and discomfort. Chronic venous hypertension can lead to skin changes, including darkening and thickening, and can also result in venous ulcers.

Major Risk Factors for Venous Insufficiency

Venous insufficiency can develop due to several risk factors. Understanding these factors can help with early identification, prevention, and management of the condition. Let’s delve into the major risk factors for venous insufficiency:


Age is a significant risk factor for venous insufficiency. As we age, the natural wear and tear on the valves in the veins that regulate blood flow can lead to venous insufficiency. This is mainly due to the loss of elasticity and weakening of the venous walls, which can impair the function of the venous valves. Thus, older adults are at a higher risk of developing this condition.


Sex is another crucial factor in the prevalence of venous insufficiency. Females tend to be more prone to this condition, mainly due to hormonal changes that relax the vein walls during cycles, pregnancy, and menopause. Additionally, hormones associated with birth control and hormone replacement therapies may increase the risk.


Genetic predisposition plays a significant role in the development of venous insufficiency. A family history of varicose veins or other venous insufficiency diseases increases the likelihood of an individual developing the condition. This is often due to the inherited vein wall strength and valve function characteristics.


Obesity can put extra pressure on the veins and impair the functionality of the venous system. The increased body weight can exacerbate the pressure in the veins in the lower limbs, particularly when standing or walking. This can lead to valve damage and, ultimately, venous insufficiency.

Sedentary Lifestyle

A sedentary lifestyle, or lack of physical activity, can contribute to developing venous insufficiency. Regular movement and muscle contractions are essential to promote blood flow from the legs to the heart. Lack of movement can lead to blood pooling in the veins of the lower limbs, thereby increasing the risk of venous insufficiency.


During pregnancy, the volume of blood in a woman’s body increases to support the growing fetus, but this can also put extra pressure on the veins. Moreover, hormonal changes during pregnancy can also dilate the veins. While venous insufficiency due to pregnancy often improves after delivery, the risk increases with each subsequent pregnancy.

Previous Deep Vein Thrombosis (DVT)

A history of DVT can increase the risk of venous insufficiency. DVT, a blood clot in the deep veins, can damage the vein valves, leading to post-thrombotic syndrome, a common cause of venous insufficiency.

Risk FactorIncreased Risk
Age2% for every decade of life
Family history2-3 times
Gender2-3 times
Obesity2-3 times
Pregnancy2-3 times
Sitting or standing for long periods1.5-2 times
Varicose veins5-10 times
Deep vein thrombosis (DVT)5-10 times
Lack of physical activity1.5-2 times
Smoking1.5-2 times


Reducing Your Risk & Prevention Strategies

Venous insufficiency, while prevalent, can be prevented or its onset delayed. In this section, we look at some strategies for reducing the risk of developing this condition.

Lifestyle Changes

Simple lifestyle modifications can significantly decrease the risk of venous insufficiency. These include avoiding sitting or standing for prolonged periods, elevating your legs whenever possible to promote blood flow, and avoiding tight clothes that can constrict your veins. Additionally, if you smoke, consider quitting, as smoking can increase inflammation and cause damage to your veins.

Exercise and Movement

Regular physical activity is essential for maintaining the health of your veins. Exercise, particularly actions that work your legs like walking, cycling, and swimming, promotes blood circulation and strengthens your veins. Incorporate regular breaks into your day to move around if your work involves extended periods of sitting or standing.

Healthy Eating

A balanced diet plays a vital role in maintaining healthy body weight and supporting overall vein health. Excess weight can pressure your veins, leading to venous insufficiency over time. Incorporate a variety of fruits, vegetables, lean proteins, and whole grains into your diet. Limit your intake of sodium, which can cause water retention and increase pressure on your veins.

Management During Pregnancy

Pregnant women are at a higher risk of venous insufficiency due to increased blood volume and hormonal changes. Wearing compression stockings, regular exercise, and elevating the legs can help prevent venous insufficiency during pregnancy. These measures can improve blood flow and reduce the pressure on the veins in the lower body.

People with a History of Deep Vein Thrombosis

If you have a history of deep vein thrombosis (DVT), taking steps to prevent venous insufficiency is crucial. Regular follow-ups with your healthcare provider, taking prescribed medications, wearing compression stockings, and maintaining a healthy lifestyle can help manage your risk.

The Progression from Venous Insufficiency to Chronic Venous Insufficiency

Venous insufficiency refers to the inability of the veins to efficiently return blood from the lower extremities back to the heart. While venous insufficiency can present with minimal symptoms initially, over time, if left untreated, it can progress to a more severe condition known as chronic venous insufficiency (CVI).

Chronic venous insufficiency develops when venous insufficiency is long-standing, and the body can no longer compensate for faulty blood circulation. This leads to blood pooling in the legs and feet over a prolonged period, which can cause various symptoms and complications.

CVI symptoms often progress over time and may include:

  • Swelling in the lower legs and ankles, especially after prolonged standing.
  • A feeling of heaviness or fatigue in the legs.
  • Pain or cramping in the legs.
  • Skin changes in the lower legs, such as thickening or discolouration (often brownish or reddish).
  • Itchy or irritated skin on the legs or ankles.
  • Development of varicose veins.
  • Slow-to-heal ulcers, typically around the ankles.

If untreated, CVI can lead to severe complications, including:

Venous ulcers: These are painful ulcers that develop on the skin, typically around the ankles, due to prolonged blood pooling. These ulcers can be challenging to heal and may require specialised wound care.

Infection: There’s an increased risk of developing skin infections (cellulitis) and potentially even blood infections (sepsis).

Deep vein thrombosis (DVT): This is a severe condition where a blood clot forms in the deeper veins of the body, often in the leg. DVT can be life-threatening if a piece of the clot breaks off and travels to the lungs, causing a pulmonary embolism.

If you observe any signs or symptoms of CVI, it’s essential to seek medical attention promptly. Effective management of venous insufficiency in the earlier stages can prevent its progression to CVI and avoid these complications.


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